منابع مشابه
Connexin 37 counteracts clotting.
The thrombotic response elicited by arterial injury or atherosclerosis varies widely between individuals; in some, diffuse coronary artery disease never triggers thrombotic occlusion, whereas others with limited disease experience myocardial infarction (MI) due to arterial thrombosis. Understanding the predictors for arterial thrombosis will improve tailored therapy for preventing and treating ...
متن کاملConnections in chronic kidney disease: connexin 43 and connexin 37 interaction.
THE PREVALENCE OF CHRONIC kidney disease is rising sharply worldwide and affects 13.1% of the population in the US (3). Patients with chronic kidney disease represent a population not only at risk of progression to end-organ failure but also at higher risk for cardiovascular diseases (22). Although inflammation is beneficial for host wound healing and defense toward infection, excessive or alte...
متن کاملConnexin 37 limits thrombus propensity by downregulating platelet reactivity.
BACKGROUND Formation of platelet plug initiates hemostasis after vascular injury and triggers thrombosis in ischemic disease. However, the mechanisms leading to the formation of a stable thrombus are poorly understood. Connexins comprise a family of proteins that form gap junctions enabling intercellular coordination of tissue activity, a process termed gap junctional intercellular communicatio...
متن کاملConnexin 37 and Connexin 43 genotypes in correlation to cytokines in induced sputum and blood in cystic fibrosis (CF)
Aims We have provided evidence in former studies that cytokines (IL-8, TNF alpha, LBP, TGFß) measured in blood correlate negatively with lung function in deltaF508 homozygous patients. GAP junction proteins might be of importance for the influx of blood cells into the lung. Our aim was to assess the relationship between connexin genotypes and cytokines (IL-8, TNF-alpha, LBP, TGFß) in induced sp...
متن کاملc1019t polymorphism in the connexin 37 gene and myocardial infarction risk in premature coronary artery disease
background: the c1019t polymorphism of the connexin-37 (gja4) gene is a single-nucleotide polymorphisms involved in atherosclerotic plaque rupture and atherosclerosis predisposition. we examined the association between the c1019t polymorphism of the gja4 gene and the occurrence of myocardial infarction (mi) in patients with premature coronary artery disease (cad). methods: our study recruited 1...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation
سال: 2011
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.111.045104